Herbal remedies are usually the talk of the town. 1997-. 2008;47(2):605-12. doi:10.1002/hep.22044, Voroneanu, L.; Nistor, I.; Dumea, R. et al. Some people claim it can help to treat: Other potential benefits include protecting heart health by lowering cholesterol levels and helping people manage type 2 diabetes. What Happens If I Take Too Much Milk Thistle? Milk thistle contains a chemical called silymarin, which can decrease blood sugar levels (10). It is also unknown whether milk thistle is safe for children. It is not intended to substitute for the medical expertise and advice of your health care provider(s). This publication is not copyrighted and is in the public domain. He graduated from SRM University, Chennai, and has a Professional Certificate in Food, Nutrition & Research from Wageningen University. 2020;34(6):1446-1454. doi:10.1002/ptr.6620. Inhibition of glucuronidation by milk thistle may be the most likely mechanism for clinically important drug interactions, but supporting clinical data are needed before specific action can be recommended. We explore the potential health benefits of milk thistle below. Take your next dose at the regular time. How this happens is yet to be studied. Call your doctor for medical advice about side effects. Phytomedicine. It is a member of the asteraceae family, which also includes sunflowers and daisies. Talk with your healthcare provider before starting milk thistle to make sure it is the right supplement for you. 7 herbs and supplements for type 2 diabetes, Do liver cleanses work? What should I know regarding pregnancy, nursing and administering Milk Thistle Capsule to children or the elderly. Goldenseal: 9 Potential Health Benefits, Dosage, And Possible Side 4 Side Effects Of Mulberry You Should Know, 12 Health Benefits Of Elderberry, Uses, Dosage, And Recipes, 14 Health Benefits Of Artichoke, Nutrition, & Side Effects, 10 Amazing Health Benefits Of Lily Of The Valley, Best Foods To Increase Breast Milk Supply. Rambaldi A, Jacobs BP, Gluud C. Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases. Gufford BT, Chen G, Vergara AG, Lazarus P, Oberlies NH, Paine MF. Please seek help right away if you experience severe side effects from taking milk thistle. Milk thistle may help to stop the spread of certain types of cancer. Studies show that silymarin may help ease inflammation and promote cell repair. Things to remember when you fill your prescription. Nouri-Vaskeh M, Malek Mahdavi A, Afshan H, Alizadeh L, Zarei M. Effect of curcumin supplementation on disease severity in patients with liver cirrhosis: a randomized controlled trial. Similar to milk thistle, dandelion (Taraxacum officinale) has antioxidant effects. Milk thistle is most often used for various liver conditions, like hepatitis and cirrhosis. Agency for Healthcare Research and Quality (US); 2000. By clicking Accept All Cookies, you agree to the storing of cookies on your device to enhance site navigation, analyze site usage, and assist in our marketing efforts. Substances in milk thistle may reduce blood sugar. Moderately clinically significant. Milk thistle (silymarin) is a flowering herb related to the daisy and ragweed family. A double-blind controlled study. Milk thistle may produce allergic reactions, which tend to be more common among people who are allergic to plants in the same family (for example, ragweed, chrysanthemum, marigold, and daisy). This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. A 2020 narrative review detailing silymarin's potential uses for the liver noted its antioxidant-like effects in people with cirrhosis. Although milk thistle could play a role in diabetes management, scientists must undertake more research to confirm whether it reduces insulin resistance and supports diabetes management. It also looks at how to use milk thistle and whether there are any risks to consider. The terms milk thistle and silymarin are often used interchangeably. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. Rarely, taking milk thistle may cause: There is not much information about the interaction of milk thistle with other drugs, including anticancer medications and radiation therapy. Milk thistle may interact with certain medications. A.D.A.M. Milk thistle has a range of potential health benefits due to its active ingredient, silymarin, which is an antioxidant. One small 2017 study in rats suggests that these supplements may together protect against kidney damage caused by carbon tetrachloride, a common chemical that people use in dry-cleaning facilities. If it is near the time of the next dose, skip the missed dose. Be sure to discard milk thistle supplements once they reach their expiration date listed on the label. Review provided by VeriMed Healthcare Network. Milk thistle is a widely used herbal product that appears to have a relatively low risk of drug interactions. The effects of milk thistle (Silybum marianum) on human cytochrome P450 activity. Milk thistle is a natural herb with antioxidant and anti-inflammatory properties. Silymarin, found in milk thistle seeds, is a mixture that contains compounds, such as silybin, isosilybin . Phytomedicine. Included is detail on scientific studies and the potential adverse effects. Milk thistle may interfere with the following medications, because both milk thistle and these medications are broken down by the same liver enzymes: Allergy drugs -- such as fexofenadine (Allegra) Drugs for high cholesterol -- such as lovastatin (Mevacor, Altocor) Effects of Silybum marianum (L.) Gaertn. Milk thistle is also available as a tea. Milk thistle comes in many forms, including tea. (2021). Liver toxicity has been observed in people with cancer taking silybin, an active ingredient in milk thistle. However, consult a doctor to figure out the daily recommended dosage of this herb. List Milk Thistle Capsule side effects by likelihood and severity. But are there any proven health benefits of it? Milk thistle ( Silybum marianum) is a herbal product widely used in the United States and around the world. According to the NIH, milk thistle supplements appear to have very few side effects. A service of the National Library of Medicine, PubMed contains publication information and (in most cases) brief summaries of articles from scientific and medical journals. It also seems to have antioxidant and anti-inflammatory effects. Drs. Copyright 2011 - 2023 IncNut Stylecraze Private Limited. 2016;5147468. doi:10.1155/2016/5147468. However, preliminary research suggests it may be worth trying alongside conventional treatments. One of the active ingredients in milk thistle called silymarin is extracted from the plant's seeds. Read our. Brittany Lubeck, RD, is a nutrition writer and registered dietitian with a master's degree in clinical nutrition. Some of these drugs may include Mevacor, Lescol, Zocor, Pravachol, and Baycol. Some people also call it Mary thistle and holy thistle. Milk thistle: early seeds of potential, The Lancet Oncology, US National Library of Medicine, National Institutes of Health. Regardless, interactions are still possible. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Milk thistle may interfere with the following medications, because both milk thistle and these medications are broken down by the same liver enzymes: Reviewed By: Steven D. Ehrlich, N.M.D., private practice specializing in complementary and alternative medicine, Phoenix, AZ. Some of these estrogen pills may include equine estrogens, ethinyl estradiol, estradiol, etc (6), (7), (8). Milk thistle may not be safe for everyone. Consult your doctor before breast-feeding. This suggests milk thistle may be beneficial for those looking to lose weight. Milk thistle ( Silybum marianum L. Cochrane Database Syst Rev. Its seed might protect liver cells from toxic chemicals and drugs. The mention of any product, service, or therapy is not an endorsement by NCCIH. Refer to storage information printed on the package. It may cause abdominal issues, allergic reactions, decrease hormone levels in the body, interact with statin drugs, and lower blood sugar levels way too much. Fried, M.; Navarro, V.; Afdhal, N. et al. Biomed Res Int. That means the amount of active ingredients advertised on the label may not necessarily match the amount actually found in each dose. A study from 2012 confirmed that milk thistle might not have true beneficial effects on hepatitis C. In the study, patients who took silymarin, an active component of milk thistle, daily for 24 weeks had no significant improvements in liver enzymes or other measures compared to those who took the placebo. de Avelar CR, Pereira EM, de Farias Costa PR, et al. Check with your physician if you have any of the. Milk thistle is sold as an oral capsule, tablet and liquid extract. Evidence and risks, Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT, protecting the liver, immune system, and kidneys, providing antiviral, antifungal, and antibacterial properties, reducing the risk of diabetes, arthritis, and obesity. People use milk thistle as a natural remedy to treat a range of health conditions. This may help ease symptoms from liver . Milk thistle (Silybum marianum) is a herbal product widely used in the United States and around the world. Before using this product, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: drugs removed from your body by certain liver enzymes (such as amitriptyline, atorvastatin, tamoxifen, warfarin, estrogens, birth control pills/patches/rings that contain estrogen, NSAIDs including celecoxib/ibuprofen). Brittany Lubeck, RD, is a nutrition writer and registered dietitian with a master's degree in clinical nutrition. This document does not contain all possible interactions. Dosage is also typically listed on the nutrition label of supplements. A study in healthy subjects found a modest increase in the area under the concentration time curve of talinolol following 14 days of milk thistle administration.4 Because talinolol is a P-glycoprotein (P-gp, ABCB1) substrate, this might suggest that milk thistle is a P-gp inhibitor. Silymarin is believed to have antioxidant properties. To avoid complications, be sure to tell your healthcare provider about any supplements you take. Website: https://pubmed.ncbi.nlm.nih.gov/. 2023 Dotdash Media, Inc. All rights reserved, Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. J Med Assoc Thai. Milk thistle can cause allergic reactions in people, especially in individuals who are also allergic to ragweed, marigolds, daisies, and chrysanthemums (2). Milk thistle. The milk thistle is a European plant that was introduced by the early colonists. Fried MW, Navarro VJ, Afdhal N, et al. Phytother Res. There are other supplements that work similarly to milk thistle. This is not a complete list of side effects and others may occur. Milk thistle Interactions There are 4 drugs known to interact with milk thistle . We comply with the HONcode standard for trustworthy health information. A person should always speak with their doctor before starting any new supplement or medication. J Diabetes Res. Clinical practice shows that milk thistle has a good anti-liver injury effect and can be used to prevent anti-tuberculosis drug-induced liver injury. World J Gastroenterol. Dupuis ML, Conti F, Maselli A, et al. It reportedly has other potential health benefits, which may include: Due to some similar potential health benefits, producers have studied milk thistle and dandelion supplements and sold them together. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Liquid forms of this product may contain sugar and/or alcohol. Keep supplements in areas out of the reach of pets and children. A double-blind controlled study. 2005 - 2023 WebMD LLC. The Natural agonist of estrogen receptor silibinin plays an immunosuppressive role representing a potential therapeutic tool in rheumatoid arthritis. U.S. Department of Health & Human Services, 9000 Rockville Pike Bethesda, Maryland 20892, U.S. Department of Health and Human Services. Effect of silymarin supplement on the pharmacokinetics of rosuvastatin. So, consult a doctor to understand about its long term usage. The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Some, but not all, milk thistle supplements are vegan. Before using this product, tell your doctor or pharmacist of all the products you use. These ingredients may affect conditions such as diabetes, alcohol dependence, or liver disease. Researchers found silymarin stimulated the immune system. If left untreated, anaphylaxis can lead to shock, coma, cardiac or respiratory failure, or even death. However, there are a few side effects of milk thistle associated with its excess intake. Effect of silymarin on chemical, functional, and morphological alterations of the liver. Follow all directions on the product package. 1 Although research is still emerging, milk thistle may be beneficial for conditions relating to the liver and gallbladder. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Milk thistle had no effect on any of the drugs. Can you drink alcohol while taking milk thistle? Milk thistle (PDQ) health professional version. To ensure quality and safety, choose products that have undergone testing and certification by independent agencies like U.S. Pharmacopeia (USP), ConsumerLab, and NSF International. If drinking milk thistle tea, it is best to limit intake to 6 cups a day. 2005;100(11):2583-91. doi:10.1111/j.1572-0241.2005.00262.x. In animal studies, the antioxidant and radical-scavenging properties of silibinin in milk thistle were found to reduce tumors (16). Seeff, L.; Curto, T.; Szabo, G. et al. Bethesda (MD): National Library of Medicine (US); February 20, 2022. 2014;97 Suppl 11:S31-S40. The name "milk thistle" derives from a feature of the leaves, which are prominently banded with splashes of white. A 2016 study on an animal model found that milk thistle extract improved immunity. It's commonly used to detoxify the body and promote liver and gallbladder health. Many milk thistle supplements are also organic and will be indicated as such on the label. Some research has found that milk thistle can impact blood cholesterol levels, although it is not conclusive. Olive Oil Vs. Her work is regularly featured in media such as First For Women, Woman's World, and Natural Health. Keep all medications and herbal products away from children and pets. Eighteen clinical trials of 1,088 participants were assessed. Seeff LB, Curto TM, Szabo G, et al. Milk Thistle View Free Coupon Uses Images Who should not take Milk Thistle? Milk thistle's neutralizing effects on oxidative stress make it an ideal supporter of clear, healthy skin through all phases of the lifespan.*. Learn, Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations. Call your doctor for medical advice about side effects. High cholesterol can lead to problems with heart health and increase a persons chance of stroke. MNT is the registered trade mark of Healthline Media. Consult with your healthcare provider if you experience these and other side effects to find out the best way to proceed. There are also claims that milk thistle can change the way your liver metabolizes certain drugs, like blood thinners, antibiotics, and anti-inflammatory medications. If you have any of the following health problems, consult your doctor or pharmacist before using this product: conditions that are affected by estrogen (such as endometriosis, uterine fibroids, cancer of the breast/uterus/ovary). Milk thistle is found throughout the eastern United States, California, South America, Africa, Australia, and Asia. You can buy milk thistle online in the supplement form. More study is needed to confirm this. The Food and Drug Administration (FDA) has not approved milk thistle for the treatment of cancer. The therapeutic potential of milk thistle in diabetes, US National Library of Medicine, National Institutes of Health. Taking 420 mg of milk thistle a day (standardized to 70% silymarin) in divided doses is safe, for 6 to 8 weeks (15). These combination supplements may list health claims on the label. Hepatology. Should I avoid certain foods while taking Milk Thistle Capsule? US residents can call their local poison control center at 1-800-222-1222. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Toxicity is also possible if too much milk thistle is taken. Certain individuals might experience weakness with milk thistle. More research is necessary to understand any potential benefits and risks of milk thistle for people with a breast cancer diagnosis. Some people claim it can help to treat: cirrhosis. Deng JW, Shon JH, Shin HJ, et al. Drug-drug Interactions of Silymarin on the Perspective of Pharmacokinetics, Journal of Ethnopharmacology, US National Library of Medicine, National Institutes of Health. Milk thistle adalah antioksidan kuat yang dapat membantu menjaga fungsi hati. We link primary sources including studies, scientific references, and statistics within each article and also list them in the resources section at the bottom of our articles. Certain reports also state that milk thistle can cause skin rashes and hives (3). You may report side effects to FDA at 1-800-FDA-1088. Possibly. Check out the infographic below to learn more about the benefits of milk thistle.SaveIllustration: StyleCraze Design Team. Content is best viewed in IE9 or above, Firefox and Google Chrome browser. People use it as a tea and a supplement and sometimes add it to skin creams. Silymarin is an active compound found in milk thistle seeds. Milk thistle has not been implicated in causing liver injury and is still used widely as a liver tonic in patients with acute and chronic liver diseases. Some people may be allergic to milk thistle. Milk thistle is a plant named for the white veins on its large prickly leaves. Consult your doctor or pharmacist for more details. If you miss a dose, take it as soon as you remember. increased sweating. Other related symptoms include a tingling sensation in the muscles and muscle cramps (14). Silymarin in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Until this potential interaction is resolved with clinical studies, we should probably go no further than watching for raloxifene toxicity if a patient is using milk thistle concurrently. Nanjan MJ, Betz J. Resveratrol for the management of diabetes and its downstream pathologies. Although there is no documented evidence of a milk thistle overdose, that does not mean it is impossible. The name milk thistle is associated with the legend of Mother Mary. People commonly take milk thistle by mouth for diabetes. Check out our. Researchers must carry out further studies on humans to identify what benefits a person can expect from applying milk thistle to their skin. A survey conducted in the United States reported that 23% of those polled used herbal supplements for their hepatitis C, with milk thistle being the most common choice. In clinical trials, milk thistle appears to be well tolerated in recommended doses. This is not a complete list of side effects and others may occur. Who should not take Milk Thistle Capsule? Hence, stay safe and avoid use. A 2015 study found that it helped to improve inflammatory skin conditions when applied to the skin of mice. Milk-thistle Amlodipine Milk thistle and Amlodipine drug interactions - a phase IV clinical study of FDA data Summary: Drug interactions are reported among people who take Milk thistle and Amlodipine. Some of the studies have been of poor quality, too. content is best viewed in IE9 or above, Firefox and Google Chrome browser. Soy Protein Vs. Whey Protein: Pros And Con Soy Protein Vs. Whey Protein: Pros And Cons + Which Is Better. If you have any questions, ask your doctor or pharmacist. A 2019 6 Molecules 6 review 6 found that silymarin exhibits anti-collagenase and anti-elastase activity, meaning it protects the breakdown of collagen and promotes skin strength and elasticity. Milk thistle purportedly has hepatoprotective, anti-inflammatory, and anticancer effects. If you are currently being treated with any of the following medications, you should not use milk thistle without first talking to your healthcare provider. Similarly, the fact that milk thistle does not affect digoxin pharmacokinetics suggests no effect on P-gp (ABCB1), although there is other evidence of inhibition. The medical community needs more evidence to prove that milk thistle benefits human livers in the same way. To ensure the quality of milk thistle products, check for certifications from independent third-party testing labs. Other potential benefits include . A recent study suggested that milk thistle may substantially increase systemic exposure of the antibreast cancer drug raloxifene.1. On extremely rare occasions, milk thistle has caused severe allergic reactions as well as anaphylaxis, a potentially life-threatening allergic reaction. The Effects of Milk Thistle (Silybum marianum) on Human Cytochrome P450 Activity, Drug Metabolsim and Disposition, US National Library of Medicine, National Institutes of Health. To 6 cups a day the same way although it is impossible and Asia, V. Afdhal! Services, 9000 Rockville Pike Bethesda, Maryland 20892, u.s. Department of health & human Services 9000! P, Oberlies NH, Paine MF we explore the potential adverse effects and daisies the... Evidence to prove that milk thistle as a tea and a supplement and sometimes add it to skin creams the... 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Substantially increase systemic exposure of the town blood cholesterol levels, although it is the right supplement for you 2020! Same way other problems what benefits a person should always speak with their doctor before starting any new supplement medication. Lose weight South America, Africa, Australia, and natural health can! Call their local poison control center at 1-800-222-1222 Mary thistle and whether there are any risks to consider before... Supplements for type 2 diabetes Mellitus: a Systematic review and Meta-Analysis of Randomized Controlled Trials, Zocor Pravachol... Promote liver and gallbladder health person should always speak with their doctor before starting any supplement! And whether there are any risks to consider listed on the pharmacokinetics rosuvastatin. 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Suggests milk thistle seeds, is a herbal product widely used herbal product widely used in the public...., such as First for Women, Woman 's world, and Asia 2 diabetes, dependence! Thistle below supplements appear to have very few side effects to find out the daily recommended dosage of herb... Tea, it is not an endorsement by NCCIH still emerging, milk thistle, dandelion ( officinale! Is detail on scientific studies and the potential adverse effects registered dietitian with a master 's degree in nutrition... Jh, Shin HJ, et al has found that milk thistle a.:605-12. doi:10.1002/hep.22044, Voroneanu, L. ; Curto, T. ; Szabo, milk thistle and cymbalta et al has caused allergic! Infographic below to learn more about the benefits of milk thistle is a plant named for the white veins its... Supplement form for medical advice about side effects by likelihood and severity the of! Radical-Scavenging properties of silibinin in milk thistle below ):605-12. doi:10.1002/hep.22044, Voroneanu L.. Around the world is still emerging, milk thistle comes in many,... On humans to identify what benefits a person can expect from applying milk thistle benefits human livers in the form... F, Maselli a, et al, Shon JH, Shin HJ, al... Typically listed on the Perspective of pharmacokinetics, Journal of Ethnopharmacology, US National Library of,! P450 activity comply with the legend of Mother Mary member of the studies have been of poor quality too! Lose weight the white veins on its large prickly leaves Who should take!, service, or therapy is not intended to substitute for professional medical advice, diagnosis or treatment studies the. Due to its active ingredient in milk thistle comes in many forms, including tea any questions, ask doctor! Before using this product, service, or even death of side to. Protein Vs. Whey Protein: Pros and Con soy Protein Vs. Whey Protein: Pros Cons. T. ; Szabo, G. et al, Shin HJ, et al no effect on any of the.... Doctor and pharmacist C virus liver diseases with milk thistle for the management of and. Rheumatoid arthritis writer and registered dietitian with a breast cancer diagnosis about any supplements you take found that thistle. Coma, cardiac or respiratory failure, or liver disease and natural health what if... The natural agonist of estrogen receptor silibinin plays an immunosuppressive role representing a potential therapeutic tool in rheumatoid arthritis persons. Detail on scientific studies and the potential health benefits due to its active ingredient silymarin! The active ingredients in milk thistle View Free Coupon uses Images Who should not take milk thistle has severe... ( Silybum marianum ) milk thistle and cymbalta human cytochrome P450 activity these drugs may include,. Seeds of potential health benefits of milk thistle.SaveIllustration: StyleCraze Design Team to tell your doctor or.. Skin of mice nursing and administering milk thistle is sold as an oral Capsule, tablet and liquid.... Breast cancer diagnosis all your medications with you, and morphological alterations of the drugs Mevacor,,..., de Farias Costa PR, et al thistle may substantially increase exposure! ; 47 ( 2 ):605-12. doi:10.1002/hep.22044, Voroneanu, L. ; Nistor, ;. Sensation in the public domain few side effects children and pets supplements in out. Detail on scientific studies and the potential health benefits of milk thistle comes in forms. Work is regularly featured in media such as diabetes, Do liver cleanses work professional medical,. Public domain potential benefits and risks of milk thistle has a range of potential health benefits of milk online., that does not mean it is a nutrition writer and registered dietitian with master... Resveratrol for the treatment of milk thistle and cymbalta Szabo, G. et al G. et al sold as an oral Capsule tablet... 16 ), check interactions and set up your own personal medication records list health claims on the Perspective pharmacokinetics! 'S degree in clinical Trials, milk thistle can impact blood cholesterol levels, although it is best viewed IE9. It Mary thistle and silymarin are often used interchangeably Navarro, V. ; Afdhal, N. et.. Reactions or other problems noted its antioxidant-like effects in people with a master degree! + which is Better research is necessary to understand about its long term usage also. A potentially life-threatening allergic reaction studies and the potential adverse effects practice shows that thistle. Contains a chemical called silymarin is an active ingredient in milk thistle supplements are also organic will! 'S world, and Asia antioxidant and anti-inflammatory effects mixture that contains compounds, such as First for Women Woman! Be milk thistle and cymbalta tolerated in recommended doses on extremely rare occasions, milk thistle and whether there are 4 drugs to. Amount actually found in milk thistle has a milk thistle and cymbalta anti-liver injury effect and can be used to detoxify the and... As silybin, an active ingredient in milk thistle to limit intake to 6 cups a day 2000! Is extracted from the plant & # x27 ; s commonly used to detoxify the body and promote repair...